Characterization of Fibrous Wollastonite NYAD G in View of Its Use as Negative Standard for In Vitro Toxicity Tests

Today, despite considerable efforts undertaken by the scientific community, mechanisms of carcinogenesis mineral fibres remain poorly understood. A crucial role in disclosing action is played vitro and vivo models. Such models require experimental design based on negative positive controls. Commonly used controls are amosite crocidolite UICC standards, while have not been identified so far. The extensive characterisation assessment toxicity/pathogenicity potential carried out this work indicate that commercial fibrous wollastonite NYAD G may be considered as a standard control for biological biomedical tests involving fibres. Preliminary suggest genotoxic. This material nearly pure characterized very long (46.6 µm), thick (3.74 µm) non-biodurable with low content metals. According to fibre toxicity index (FPTI) model, an inert expected exert response during vitro/in testing.